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DSG2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14126 |
| Other Accession | NP_001934.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 122294 Da |
| Antigen Region | 829-857 aa |
| Gene ID | 1829 |
|---|---|
| Other Names | Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5 |
| Target/Specificity | This DSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-857 amino acids from the C-terminal region of human DSG2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DSG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DSG2 |
|---|---|
| Synonyms | CDHF5 |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome |
| Tissue Location | All of the tissues tested and carcinomas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Fressart, V., et al. Europace 12(6):861-868(2010)
Schlegel, N., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (5), G774-G783 (2010) :
Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
Buxens, A., et al. Scand J Med Sci Sports (2010) In press :
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