CTDSP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O14595 |
Other Accession | NP_005721.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 30664 Da |
Antigen Region | 11-39 aa |
Gene ID | 10106 |
---|---|
Other Names | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4, SCP2 |
Target/Specificity | This CTDSP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human CTDSP2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CTDSP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTDSP2 |
---|---|
Synonyms | NIF2, OS4, SCP2 |
Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
Cellular Location | Nucleus. |
Tissue Location | Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Sapkota, G., et al. J. Biol. Chem. 281(52):40412-40419(2006)
Thompson, J., et al. EMBO J. 25(12):2757-2767(2006)
Yeo, M., et al. J. Biol. Chem. 278(28):26078-26085(2003)
Su, Y.A., et al. Oncogene 15(11):1289-1294(1997)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.