CARD10 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BWT7 |
Other Accession | NP_055365.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 115931 Da |
Antigen Region | 518-546 aa |
Gene ID | 29775 |
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Other Names | Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3, CARD10, CARMA3 |
Target/Specificity | This CARD10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the Central region of human CARD10. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CARD10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CARD10 |
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Synonyms | CARMA3 |
Function | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. |
Cellular Location | Cytoplasm. |
Tissue Location | Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)
Martin, D., et al. J. Biol. Chem. 284(10):6038-6042(2009)
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