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HOXC4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P09017 |
| Other Accession | Q08624, NP_055435.2, NP_705897.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29811 Da |
| Antigen Region | 197-225 aa |
| Gene ID | 3221 |
|---|---|
| Other Names | Homeobox protein Hox-C4, Homeobox protein CP19, Homeobox protein Hox-3E, HOXC4, HOX3E |
| Target/Specificity | This HOXC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human HOXC4. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HOXC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HOXC4 |
|---|---|
| Synonyms | HOX3E |
| Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.
References
Park, S.R., et al. Nat. Immunol. 10(5):540-550(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Gong, L.G., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22(5):497-501(2005)
Kim, E.C., et al. J. Biol. Chem. 279(40):42258-42269(2004)
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