RRP1B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q14684 |
Other Accession | NP_055871.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 84428 Da |
Antigen Region | 571-598 aa |
Gene ID | 23076 |
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Other Names | Ribosomal RNA processing protein 1 homolog B, RRP1-like protein B, RRP1B, KIAA0179 |
Target/Specificity | This RRP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-598 amino acids from the N-terminal region of human RRP1B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RRP1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RRP1B |
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Synonyms | KIAA0179 |
Function | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). |
Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015) |
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Provided below are standard protocols that you may find useful for product applications.
Background
RRP1B belongs to the RRP1 family. It may be a novel susceptibility gene for breast cancer progression and metastasis.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Paik, J.C., et al. J. Biol. Chem. 285(9):6348-6363(2010)
Crawford, N.P., et al. J. Biol. Chem. 284(42):28660-28673(2009)
Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :
Crawford, N.P., et al. PLoS Genet. 3 (11), E214 (2007) :
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