Mouse Tp53rk Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q99PW4 |
Other Accession | NP_076304.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27394 Da |
Antigen Region | 100-128 aa |
Other Names | TP53-regulating kinase, Atypical serine/threonine protein kinase Tp53rk, EKC/KEOPS complex subunit Tp53rk, 36--, Nori-2, p53-related protein kinase, Tp53rk, Prpk, Trp53rk |
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Target/Specificity | This Mouse Tp53rk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of mouse Tp53rk. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Tp53rk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Tp53rkb {ECO:0000305} |
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Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q96S44}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tp53rk is a protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (By similarity).
References
Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Abe, Y., et al. J. Biol. Chem. 276(47):44003-44011(2001)
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