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KCNK10 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57789 |
| Other Accession | NP_066984.1, NP_612190.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59765 Da |
| Antigen Region | 504-532 aa |
| Gene ID | 54207 |
|---|---|
| Other Names | Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2 |
| Target/Specificity | This KCNK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-532 amino acids from the C-terminal region of human KCNK10. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNK10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNK10 {ECO:0000303|PubMed:25766236, ECO:0000312|HGNC:HGNC:6273} |
|---|---|
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids (PubMed:10880510, PubMed:25766236, PubMed:26919430, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:30573346). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (PubMed:26919430). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BUW1}; Multi-pass membrane protein |
| Tissue Location | [Isoform A]: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. In brain, mainly expressed in cerebellum, occipital lobe, putamen, and thalamus. No expression is detected in amygdala and spinal cord. [Isoform C]: Abundantly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq].
References
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)
Huang, D., et al. Med. Hypotheses 70(3):618-624(2008)
Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)
Gu, W., et al. J. Physiol. (Lond.) 539 (PT 3), 657-668 (2002) :
Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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