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CREB5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02930 |
| Other Accession | NP_001011666.1, NP_004895.2, NP_878901.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56918 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 9586 |
|---|---|
| Other Names | Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, CRE-BPa, CREB5, CREBPA |
| Target/Specificity | This CREB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CREB5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CREB5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CREB5 |
|---|---|
| Synonyms | CREBPA |
| Function | Binds to the cAMP response element and activates transcription. |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
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