ADAM11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75078 |
Other Accession | NP_002381.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 83418 Da |
Antigen Region | 200-228 aa |
Gene ID | 4185 |
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Other Names | Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC |
Target/Specificity | This ADAM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the N-terminal region of human ADAM11. |
Dilution | WB~~1:500 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ADAM11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADAM11 |
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Synonyms | MDC |
Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (By similarity). Plays a role in spatial learning and motor coordination (By similarity). Involved in the nociceptive pain response to chemical-derived stimulation (By similarity). |
Cellular Location | Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4} |
Tissue Location | Expressed predominantly in brain. Slightly detected or not at all in other tissues |
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Background
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq].
References
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Shea, S.H., et al. Behav. Genet. 31(2):231-239(2001)
Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :
Wolfsberg, T.G., et al. J. Cell Biol. 131(2):275-278(1995)
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