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P2RX5 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - P2RX5 Antibody (C-term) AP14059b
    P2RX5 Antibody (C-term) (Cat. #AP14059b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the P2RX5 antibody detected the P2RX5 protein (arrow).
    detail
  • IHC-P - P2RX5 Antibody (C-term) AP14059b
    P2RX5 Antibody (C-term) (AP14059b)immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of P2RX5 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q93086
Other Accession NP_002552.2, NP_778255.1, NP_778256.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 49303 Da
Antigen Region 325-353 aa
Additional Information
Gene ID 5026
Other Names P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5
Target/Specificity This P2RX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-353 amino acids from the C-terminal region of human P2RX5.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsP2RX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name P2RX5 (HGNC:8536)
Function [Isoform 6]: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:12761352). Unlike, other P2RX receptors, the P2X5 receptor is also permeable to chloride (PubMed:12761352). May play a supporting role in the inflammatory response (By similarity).
Cellular Location [Isoform 6]: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=The absence of the exon 10-encoded amino acids substantially results in subunit aggregation and retention in the cell cytoplasm
Tissue Location Expressed at high levels in brain and immune system
Research Areas
Citations (0)
citation

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Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.

References

Kotnis, S., et al. Mol. Pharmacol. 77(6):953-960(2010)
Overes, I.M., et al. Cancer Immunol. Immunother. 58(3):429-439(2009)
Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Duckwitz, W., et al. J. Biol. Chem. 281(51):39561-39572(2006)

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$ 365.00
$ 140.00
Cat# AP14059b
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