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MYB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P10242 |
| Other Accession | NP_001123645.1, NP_001123644.1, NP_005366.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72341 Da |
| Antigen Region | 419-448 aa |
| Gene ID | 4602 |
|---|---|
| Other Names | Transcriptional activator Myb, Proto-oncogene c-Myb, MYB |
| Target/Specificity | This MYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-448 amino acids from the Central region of human MYB. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYB |
|---|---|
| Function | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:19646965} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Tanno, B., et al. J. Biol. Chem. 285(38):29434-29445(2010)
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)
Stenman, G., et al. Cell Cycle 9(15):2986-2995(2010)
Deisenroth, C., et al. Mol. Cell. Biol. 30(16):3981-3993(2010)
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