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VAV1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P15498 |
| Other Accession | NP_005419.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98314 Da |
| Antigen Region | 437-466 aa |
| Gene ID | 7409 |
|---|---|
| Other Names | Proto-oncogene vav, VAV1, VAV |
| Target/Specificity | This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VAV1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VAV1 |
|---|---|
| Synonyms | VAV |
| Function | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| Tissue Location | Widely expressed in hematopoietic cells but not in other cell types |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Hollmann, A., et al. Hematol Oncol 28(3):142-150(2010)
Barda-Saad, M., et al. EMBO J. 29(14):2315-2328(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kim, H.S., et al. Immunity 32(2):175-186(2010)
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