IL21 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
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Primary Accession | Q9HBE4 |
Other Accession | NP_068575.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 18653 Da |
Antigen Region | 104-132 aa |
Gene ID | 59067 |
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Other Names | Interleukin-21, IL-21, Za11, IL21 |
Target/Specificity | This IL21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the C-terminal region of human IL21. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IL21 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IL21 (HGNC:6005) |
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Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed:11081504, PubMed:15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). |
Cellular Location | Secreted. |
Tissue Location | Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes |
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Background
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B-and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
References
Petukhova, L., et al. Nature 466(7302):113-117(2010)
Yue, F.Y., et al. J. Immunol. 185(1):498-506(2010)
Pallone, F., et al. Expert Rev Clin Immunol 6(4):537-541(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Hollis-Moffatt, J.E., et al. Arthritis Res. Ther. 12 (3), R116 (2010) :
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