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Mouse Camk2d Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6PHZ2 |
| Other Accession | Q9DG02, P15791, O77708, Q95266, Q13557, Q5ZKI0, Q2HJF7, P11275, P11798, Q9UQM7, Q6DGS3, Q6DEH3, NP_001020609.1, NP_076302.1 |
| Reactivity | Human, Mouse |
| Predicted | Zebrafish, Rat, Bovine, Chicken, Pig, Rabbit, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56369 Da |
| Antigen Region | 221-250 aa |
| Gene ID | 108058 |
|---|---|
| Other Names | Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, Camk2d, Kiaa4163 |
| Target/Specificity | This Mouse Camk2d antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the Central region of mouse Camk2d. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Camk2d Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Camk2d |
|---|---|
| Synonyms | Kiaa4163 |
| Function | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport (PubMed:12676814, PubMed:15456698, PubMed:17124532). Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure (PubMed:12676814, PubMed:19179290, PubMed:19381018). Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:20194790). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction (PubMed:15793582). In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure (PubMed:17124532). Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency- dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). |
| Cellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in cardiac muscle and skeletal muscle. Isoform Delta 2, isoform Delta 6, isoform Delta 6 and isoform Delta 10 are expressed in cardiac muscle. Isoform Delta 2 is expressed in skeletal muscle. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release (By similarity).
References
Martinez-Pena y Valenzuela, I., et al. J. Neurosci. 30(37):12455-12465(2010)
Toko, H., et al. Circulation 122(9):891-899(2010)
Kushnir, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10274-10279(2010)
Mangmool, S., et al. J. Cell Biol. 189(3):573-587(2010)
Koval, O.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):4996-5000(2010)
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$ 365.00
$ 140.00
Cat# AP13799c
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