PPP2CB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | P62714 |
Other Accession | P23696, P62716, P11611, P11493, P62715, Q0P594, P63331, P67777, P67776, P63330, P67775, P48463, P67774, NP_001009552.1, G5EGK8 |
Reactivity | Human |
Predicted | Bovine, Chicken, Mouse, Pig, Rabbit, Rat, C.Elegans, Drosophila |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 35575 Da |
Antigen Region | 278-307 aa |
Gene ID | 5516 |
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Other Names | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-beta, PPP2CB |
Target/Specificity | This PPP2CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-307 amino acids from the C-terminal region of human PPP2CB. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PPP2CB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PPP2CB (HGNC:9300) |
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Function | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). |
Cellular Location | Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles |
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Provided below are standard protocols that you may find useful for product applications.
Background
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
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