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CSK Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CSK Antibody (N-term) AP13748a
    CSK Antibody (N-term) (Cat. #AP13748a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CSK antibody detected the CSK protein (arrow).
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  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P41240
Other Accession P32577, P41241, P41239, Q0VBZ0, NP_001120662.1, NP_004374.1
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50704 Da
Antigen Region 33-61 aa
Additional Information
Gene ID 1445
Other Names Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK
Target/Specificity This CSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human CSK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCSK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSK
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Cellular Location Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
Tissue Location Expressed in lung and macrophages.
Research Areas
Citations ( 0 )

Background

Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.

References

Niu, W., et al. Clin. Chim. Acta 411 (19-20), 1491-1495 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Mikkola, E.T., et al. J. Mol. Biol. 399(4):618-627(2010)
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)

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$ 182.50
$ 70.00
Cat# AP13748a
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