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ATG9B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q674R7 |
| Other Accession | NP_775952.4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101019 Da |
| Antigen Region | 892-921 aa |
| Gene ID | 285973 |
|---|---|
| Other Names | Autophagy-related protein 9B, APG9-like 2, Nitric oxide synthase 3-overlapping antisense gene protein, Protein sONE, ATG9B, APG9L2, NOS3AS |
| Target/Specificity | This ATG9B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 892-921 amino acids from the C-terminal region of human ATG9B. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ATG9B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATG9B |
|---|---|
| Function | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). |
| Cellular Location | Preautophagosomal structure membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157). |
| Tissue Location | Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ATG9B plays a role in autophagy (By similarity).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Han, S., et al. Hum. Immunol. 71(7):727-730(2010) Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010) Webber, J.L., et al. FEBS Lett. 584(7):1319-1326(2010) Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
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