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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > ATG2A Antibody (Center)
ATG2A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q2TAZ0 |
| Other Accession | NP_055919.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 212860 Da |
| Antigen Region | 702-731 aa |
| Gene ID | 23130 |
|---|---|
| Other Names | Autophagy-related protein 2 homolog A, ATG2A, KIAA0404 |
| Target/Specificity | This ATG2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 702-731 amino acids from the Central region of human ATG2A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ATG2A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATG2A {ECO:0000303|PubMed:21887408, ECO:0000312|HGNC:HGNC:29028} |
|---|---|
| Function | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). |
| Cellular Location | Preautophagosomal structure membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96BY7}. Lipid droplet {ECO:0000250|UniProtKB:Q96BY7}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}. Note=Localizes to endoplasmic reticulum-autophagosome contact sites. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Guru, S.C., et al. Genome Res. 7(7):725-735(1997)
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$ 385.00
$ 150.00
Cat# AP13648c
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