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TRIM31 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZY9 |
| Other Accession | NP_008959.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48244 Da |
| Antigen Region | 279-307 aa |
| Gene ID | 11074 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM31, 632-, Tripartite motif-containing protein 31, TRIM31, C6orf13, RNF |
| Target/Specificity | This TRIM31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-307 amino acids from the C-terminal region of human TRIM31. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM31 {ECO:0000303|PubMed:11331580, ECO:0000312|HGNC:HGNC:16289} |
|---|---|
| Function | E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity). |
| Cellular Location | Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria (PubMed:18773414). Recruited t omitochondria after viral infection (PubMed:27992402). |
| Tissue Location | Up-regulated in gastric adenocarcinomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Shiina, T., et al. Genetics 173(3):1555-1570(2006)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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