SGMS1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q86VZ5 |
Other Accession | Q8VCQ6, NP_671512.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 48617 Da |
Antigen Region | 24-53 aa |
Gene ID | 259230 |
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Other Names | Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1, MOB, SMS1, TMEM23 |
Target/Specificity | This SGMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human SGMS1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SGMS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SGMS1 |
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Synonyms | MOB, SMS1, TMEM23 |
Function | Major sphingomyelin synthase at the Golgi apparatus (PubMed:14685263, PubMed:17449912). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (PubMed:14685263, PubMed:14976195, PubMed:17449912, PubMed:17982138, PubMed:19454763). Does not use free phosphorylcholine or CDP-choline as donor (PubMed:14685263, PubMed:14976195). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:14976195, PubMed:17449912, PubMed:17982138). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337). |
Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
Tissue Location | Brain, heart, kidney, liver, muscle and stomach. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lafont, E., et al. Cell Death Differ. 17(4):642-654(2010)
Vacaru, A.M., et al. J. Cell Biol. 185(6):1013-1027(2009)
Wang, W., et al. Plant Cell 20(11):3163-3179(2008)
Jin, Z.X., et al. Int. Immunol. 20(11):1427-1437(2008)
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