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PROC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, IHC-P, WB, E |
|---|---|
| Primary Accession | P04070 |
| Other Accession | NP_000303.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52071 Da |
| Antigen Region | 177-206 aa |
| Gene ID | 5624 |
|---|---|
| Other Names | Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC |
| Target/Specificity | This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC. |
| Dilution | IF~~1:10~50 WB~~1:500-1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PROC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PROC |
|---|---|
| Function | Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). |
| Cellular Location | Secreted. Golgi apparatus Endoplasmic reticulum |
| Tissue Location | Plasma; synthesized in the liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
References
Tang, W., et al. Blood (2010) In press :
Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)
Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)
Zhang, L., et al. Blood 80(4):942-952(1992)
Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
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