DEGS1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | O15121 |
Other Accession | NP_003667.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37866 Da |
Antigen Region | 1-30 aa |
Gene ID | 8560 |
---|---|
Other Names | Sphingolipid delta(4)-desaturase DES1, 114--, Cell migration-inducing gene 15 protein, Degenerative spermatocyte homolog 1, Membrane lipid desaturase, DEGS1, DES1, MLD |
Target/Specificity | This DEGS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DEGS1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DEGS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DEGS1 (HGNC:13709) |
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Synonyms | DES1, MLD |
Function | Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (PubMed:11937514, PubMed:30620337, PubMed:30620338). Catalyzes the equilibrium isomerization of retinols (By similarity). |
Cellular Location | Mitochondrion membrane. Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.
References
Idkowiak-Baldys, J., et al. Biochem. J. 427(2):265-274(2010)
Kraveka, J.M., et al. J. Biol. Chem. 282(23):16718-16728(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Ternes, P., et al. J. Biol. Chem. 277(28):25512-25518(2002)
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