Thioredoxin 2 (Trx2) Antibody (c-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q99757 |
Other Accession | P97615, P97493, Q95108 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 18383 Da |
Antigen Region | 136-166 aa |
Gene ID | 25828 |
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Other Names | Thioredoxin, mitochondrial, MTRX, Mt-Trx, Thioredoxin-2, TXN2, TRX2 |
Target/Specificity | This Thioredoxin 2 (Trx2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-166 amino acids from the C-terminal region of human Thioredoxin 2 (Trx2). |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Thioredoxin 2 (Trx2) Antibody (c-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TXN2 |
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Synonyms | TRX2 |
Function | Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. |
Cellular Location | Mitochondrion |
Tissue Location | Widely expressed in adult (at protein level) and fetal tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRX2 is a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
References
J. Biol. Chem. 277 (36), 33249-33257 (2002)
J. Biol. Chem. 277 (36), 33242-33248 (2002)
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