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NDUFAF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8N183 |
| Other Accession | NP_777549.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19856 Da |
| Antigen Region | 71-99 aa |
| Gene ID | 91942 |
|---|---|
| Other Names | Mimitin, mitochondrial, B172-like, B172L, Myc-induced mitochondrial protein, MMTN, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein, NDUFAF2, NDUFA12L |
| Target/Specificity | This NDUFAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the Central region of human NDUFAF2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NDUFAF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NDUFAF2 |
|---|---|
| Synonyms | NDUFA12L |
| Function | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lesch, K.P., et al. Mol. Psychiatry (2010) In press :
Herzer, M., et al. Neuropediatrics 41(1):30-34(2010)
Hoefs, S.J., et al. Hum. Mutat. 30 (7), E728-E736 (2009) :
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
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