CCDC134 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9H6E4 |
Other Accession | Q5M862, NP_079097.1 |
Reactivity | Human |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26561 Da |
Antigen Region | 197-225 aa |
Gene ID | 79879 |
---|---|
Other Names | Coiled-coil domain-containing protein 134, CCDC134 |
Target/Specificity | This CCDC134 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human CCDC134. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CCDC134 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCDC134 |
---|---|
Function | In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939). |
Cellular Location | Nucleus. Cytoplasm. Secreted Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376) |
Tissue Location | Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Huang, J., et al. Cell. Mol. Life Sci. 65(2):338-349(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Dunham, I., et al. Nature 402(6761):489-495(1999)
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