SLC16A10 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, IHC-P, E |
---|---|
Primary Accession | Q8TF71 |
Other Accession | NP_061063.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55493 Da |
Antigen Region | 301-329 aa |
Gene ID | 117247 |
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Other Names | Monocarboxylate transporter 10, MCT 10, Aromatic amino acid transporter 1, Solute carrier family 16 member 10, T-type amino acid transporter 1, SLC16A10, MCT10, TAT1 |
Target/Specificity | This SLC16A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-329 amino acids from the C-terminal region of human SLC16A10. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC16A10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC16A10 |
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Synonyms | MCT10, TAT1 {ECO:0000303|PubMed:11827462 |
Function | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4- dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91Y77}; Multi-pass membrane protein |
Tissue Location | Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.
References
Loubiere, L.S., et al. Placenta 31(4):295-304(2010)
Friesema, E.C., et al. Mol. Endocrinol. 22(6):1357-1369(2008)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Park, S.Y., et al. Arch. Pharm. Res. 28(4):421-432(2005)
Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
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