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WNT16 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UBV4 |
| Other Accession | Q9QYS1, NP_476509.1, NP_057171.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40690 Da |
| Antigen Region | 236-265 aa |
| Gene ID | 51384 |
|---|---|
| Other Names | Protein Wnt-16, WNT16 |
| Target/Specificity | This WNT16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-265 amino acids from the C-terminal region of human WNT16. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WNT16 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WNT16 |
|---|---|
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
References
Binet, R., et al. Cancer Res. 69(24):9183-9191(2009)
Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)
Nygren, M.K., et al. Exp. Hematol. 37(2):225-233(2009)
Teh, M.T., et al. J. Cell. Sci. 120 (PT 2), 330-339 (2007) :
Casagrande, G., et al. Haematologica 91(6):765-771(2006)
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