ZP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P60852 |
Other Accession | NP_997224.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 70049 Da |
Antigen Region | 536-565 aa |
Gene ID | 22917 |
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Other Names | Zona pellucida sperm-binding protein 1, Zona pellucida glycoprotein 1, Zp-1, Processed zona pellucida sperm-binding protein 1, ZP1 |
Target/Specificity | This ZP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human ZP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZP1 |
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Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida. |
Cellular Location | [Processed zona pellucida sperm-binding protein 1]: Zona pellucida |
Tissue Location | Expressed in oocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
References
Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)
Ganguly, A., et al. Hum. Reprod. 25(7):1643-1656(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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