AMELX Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q99217 |
Other Accession | NP_872621.1, NP_001133.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21603 Da |
Antigen Region | 17-46 aa |
Gene ID | 265 |
---|---|
Other Names | Amelogenin, X isoform, AMELX, AMG, AMGX |
Target/Specificity | This AMELX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human AMELX. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AMELX Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AMELX |
---|---|
Synonyms | AMG, AMGX |
Function | Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Almqvist, S., et al. J Mater Sci Mater Med 21(3):947-954(2010)
Lee, S.K., et al. J. Dent. Res. 89(1):46-50(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Tomas, C., et al. Forensic Sci Int Genet 3(1):1-6(2008)
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