RARRES1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | P49788 |
Other Accession | NP_002879.2, NP_996846.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33285 Da |
Antigen Region | 134-163 aa |
Gene ID | 5918 |
---|---|
Other Names | Retinoic acid receptor responder protein 1, Phorbol ester-induced gene 1 protein, PERG-1, RAR-responsive protein TIG1, Tazarotene-induced gene 1 protein, RARRES1, PEIG1, TIG1 |
Target/Specificity | This RARRES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the C-terminal region of human RARRES1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RARRES1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RARRES1 |
---|---|
Synonyms | PEIG1, TIG1 |
Function | Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. |
Cellular Location | Membrane; Single- pass type III membrane protein. Secreted |
Tissue Location | Detected in urine (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
References
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Kwok, W.K., et al. Cancer Genet. Cytogenet. 194(1):58-64(2009)
Ohnishi, S., et al. Cell Prolif. 42(3):309-316(2009)
Son, M.S., et al. Oncol. Res. 17 (11-12), 571-580 (2009) :
Shutoh, M., et al. Cancer 104(8):1609-1619(2005)
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