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GRIK3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q13003 |
| Other Accession | P42264, B1AS29, Q38PU2, NP_000822.2 |
| Reactivity | Mouse |
| Predicted | Monkey, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104037 Da |
| Antigen Region | 70-98 aa |
| Gene ID | 2899 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 3, GluK3, Excitatory amino acid receptor 5, EAA5, Glutamate receptor 7, GluR-7, GluR7, GRIK3, GLUR7 |
| Target/Specificity | This GRIK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human GRIK3. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRIK3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRIK3 |
|---|---|
| Synonyms | GLUR7 |
| Function | Ionotropic glutamate receptor that functions as a cation- permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:7719709). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P42264}; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42264}; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Luciano, M., et al. Behav. Genet. 40(4):518-532(2010)
Kilic, G., et al. Psychiatry Res 175 (1-2), 43-46 (2010) :
Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)
Ahmad, Y., et al. World J. Biol. Psychiatry 10(4):330-333(2009)
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