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HERV-FRD Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 6
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P60508 |
| Other Accession | P61556, NP_997465.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59523 Da |
| Antigen Region | 79-107 aa |
| Gene ID | 405754 |
|---|---|
| Other Names | Syncytin-2, Endogenous retrovirus group FRD member 1, Envelope polyprotein, HERV-FRD, HERV-FRD_6p241 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERVFRD-1, ERVFRDE1 |
| Target/Specificity | This HERV-FRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the N-terminal region of human HERV-FRD. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HERV-FRD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ERVFRD-1 |
|---|---|
| Synonyms | ERVFRDE1 |
| Function | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). |
| Cellular Location | Virion. [Transmembrane protein]: Cell membrane; Single-pass membrane protein |
| Tissue Location | Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. |
Provided below are standard protocols that you may find useful for product applications.
Background
Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).
References
Vargas, A., et al. J. Mol. Biol. 392(2):301-318(2009)
Chen, C.P., et al. Biol. Reprod. 79(5):815-823(2008)
Malassine, A., et al. Retrovirology 5, 6 (2008) :
Mangeney, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(51):20534-20539(2007)
Malassine, A., et al. Placenta 28 (2-3), 185-191 (2007) :
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