ZHX3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H4I2 |
Other Accession | NP_055850.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 104658 Da |
Antigen Region | 645-674 aa |
Gene ID | 23051 |
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Other Names | Zinc fingers and homeoboxes protein 3, Triple homeobox protein 1, Zinc finger and homeodomain protein 3, ZHX3, KIAA0395, TIX1 |
Target/Specificity | This ZHX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645-674 amino acids from the C-terminal region of human ZHX3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZHX3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZHX3 |
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Synonyms | KIAA0395, TIX1 |
Function | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12659632} |
Tissue Location | Widely expressed. High expression in kidney. Expressed during osteogenic differentiation |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.
References
Liu, G., et al. J. Biol. Chem. 281(51):39681-39692(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Kawata, H., et al. Gene 323, 133-140 (2003) :
Yamada, K., et al. Biochem. J. 373 (PT 1), 167-178 (2003) :
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