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BCAT2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O15382 |
| Other Accession | NP_001158245.1, NP_001181.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44288 Da |
| Antigen Region | 309-336 aa |
| Gene ID | 587 |
|---|---|
| Other Names | Branched-chain-amino-acid aminotransferase, mitochondrial, BCAT(m), Placental protein 18, PP18, BCAT2, BCATM, BCT2, ECA40 |
| Target/Specificity | This BCAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-336 amino acids from the C-terminal region of human BCAT2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCAT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCAT2 |
|---|---|
| Function | Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:17050531, PubMed:25653144, PubMed:8702755). May also function as a transporter of branched chain alpha-keto acids (By similarity). |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:O35854}. |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Coles, S.J., et al. Biochemistry 48(3):645-656(2009)
Yennawar, N.H., et al. J. Biol. Chem. 281(51):39660-39671(2006)
Goto, M., et al. J. Biol. Chem. 280(44):37246-37256(2005)
Conway, M.E., et al. Biochemistry 43(23):7356-7364(2004)
Yennawar, N., et al. Acta Crystallogr. D Biol. Crystallogr. 57 (PT 4), 506-515 (2001) :
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