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GPR34 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GPR34 Antibody (Center) AP12840C
    GPR34 Antibody (Center) (Cat. #AP12840c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GPR34 antibody detected the GPR34 protein (arrow).
    detail
  • IHC-P - GPR34 Antibody (Center) AP12840C
    GPR34 Antibody (Center) (Cat. #AP12840c)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPR34 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9UPC5
Other Accession Q9R1K6, NP_001091048.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43860 Da
Antigen Region 232-261 aa
Additional Information
Gene ID 2857
Other Names Probable G-protein coupled receptor 34, GPR34
Target/Specificity This GPR34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human GPR34.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPR34 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR34
Function G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:16460680). Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils (By similarity). Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production (By similarity). Plays an important role in microglial function, controlling morphology and phagocytosis (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Broadly expressed. Highly expressed on mast cells (PubMed:16460680).
Research Areas
Citations ( 0 )

Background

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.

References

Engemaier, E., et al. Genomics 87(2):254-264(2006)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Jacobi, F.K., et al. Hum. Genet. 107(1):89-91(2000)
Schoneberg, T., et al. Biochim. Biophys. Acta 1446 (1-2), 57-70 (1999) :
Marchese, A., et al. Genomics 56(1):12-21(1999)

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$ 182.50
$ 70.00
Cat# AP12840C
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