Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
UBAP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q5T6F2 |
| Other Accession | NP_060919.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 117116 Da |
| Antigen Region | 144-173 aa |
| Gene ID | 55833 |
|---|---|
| Other Names | Ubiquitin-associated protein 2, UBAP-2, UBAP2 {ECO:0000312|EMBL:AAI117631} |
| Target/Specificity | This UBAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human UBAP2. |
| Dilution | IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBAP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBAP2 {ECO:0000312|EMBL:AAI11763.1} |
|---|---|
| Function | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a novel gene isolated based on its expression in the human adrenal gland. The full-length protein encoded by this gene contains a UBA-domain (ubiquitin associated domain), which is a motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. In addition, the protein contains a region similar to a domain found in members of the atrophin-1 family. The function of this protein has not been determined. Additional alternate splice variants may exist, but their full length nature has not been determined.
References
Venturelli, E., et al. Neurosci. Lett. 482(3):240-244(2010)
Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
