EXTL3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O43909 |
Other Accession | Q9WVL6, NP_001431.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 104749 Da |
Antigen Region | 345-374 aa |
Gene ID | 2137 |
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Other Names | Exostosin-like 3, EXT-related protein 1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, EXTL3, EXTL1L, EXTR1, KIAA0519 |
Target/Specificity | This EXTL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the N-terminal region of human EXTL3. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EXTL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EXTL3 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:3518} |
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Function | Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) (PubMed:28132690, PubMed:28148688). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker (PubMed:11390981, PubMed:35676258). May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity) (PubMed:11390981, PubMed:35676258). Lacks glucuronyl transferase II (GlcAT-II) activity (PubMed:11390981, PubMed:35676258). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:11390981, PubMed:22727489, PubMed:28132690, PubMed:28148688, PubMed:35676258). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus. Cell membrane. Nucleus Note=Interaction with REG3A induces its translocation to the nucleus |
Tissue Location | Ubiquitous. Expressed in keratinocytes. Expressed in pancreas (PubMed:34099862). |
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Provided below are standard protocols that you may find useful for product applications.
Background
EXTL3 is probable glycosyltransferase (By similarity).
References
Kaidonis, X., et al. Eur. J. Hum. Genet. 18(2):194-199(2010)
Pata, G., et al. J Surg Oncol 100(6):520-522(2009)
Levetan, C.S., et al. Endocr Pract 14(9):1075-1083(2008)
Karibe, T., et al. J. Pathol. 216(1):32-42(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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