DRG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9Y295 |
Other Accession | P32233, Q3MHP5, NP_004138.1 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40542 Da |
Antigen Region | 334-363 aa |
Gene ID | 4733 |
---|---|
Other Names | Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3 |
Target/Specificity | This DRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the C-terminal region of human DRG1. |
Dilution | WB~~1:2000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DRG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029} |
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Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
Cellular Location | Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes |
Tissue Location | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
DRG1 may play a role in cell proliferation, differentiation and death.
References
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Bandyopadhyay, S., et al. Cancer Res. 66(24):11983-11990(2006)
Bandyopadhyay, S., et al. Oncogene 23(33):5675-5681(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Bandyopadhyay, S., et al. Cancer Res. 63(8):1731-1736(2003)
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