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ME2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ME2 Antibody (C-term) AP12610b
    ME2 Antibody (C-term) (Cat. #AP12610b) western blot analysis in mouse NIH-3T3,Neuro-2a cell line lysates (35ug/lane).This demonstrates the ME2 antibody detected the ME2 protein (arrow).
    detail
  • IHC-P - ME2 Antibody (C-term) AP12610b
    ME2 Antibody (C-term) (Cat. #AP12610b)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ME2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P23368
Other Accession NP_002387.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 65444 Da
Antigen Region 527-556 aa
Additional Information
Gene ID 4200
Other Names NAD-dependent malic enzyme, mitochondrial, NAD-ME, Malic enzyme 2, ME2
Target/Specificity This ME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human ME2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsME2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ME2
Function NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
Cellular Location Mitochondrion matrix
Research Areas
Citations (0)
citation

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Background

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq].

References

MacDonald, M.J., et al. Arch. Biochem. Biophys. 488(2):100-104(2009)
French, D., et al. Blood 113(19):4512-4520(2009)
Escamilla, M. Pharmacogenomics 8(7):691-695(2007)
Chou, W.Y., et al. Biochem. Biophys. Res. Commun. 357(1):133-138(2007)
Lenzen, K.P., et al. Epilepsia 46(10):1637-1641(2005)

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$ 365.00
$ 140.00
Cat# AP12610b
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