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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ASS1 Antibody (C-term)   

ASS1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ASS1 Antibody (C-term) AP12606b
    Western blot analysis of ASS1 (arrow) using rabbit polyclonal ASS1 Antibody (C-term) (Cat. #AP12606b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASS1 gene.
    detail
  • WB - ASS1 Antibody (C-term) AP12606b
    ASS1 Antibody (C-term) (Cat. #AP12606b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ASS1 antibody detected the ASS1 protein (arrow).
    detail
  • IHC-P - ASS1 Antibody (C-term) AP12606b
    ASS1 Antibody (C-term) (Cat. #AP12606b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ASS1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • FC - ASS1 Antibody (C-term) AP12606b
    ASS1 Antibody (C-term) (Cat. #AP12606b) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession P00966
Other Accession P09034, P16460, Q5ZJ23, P14568, NP_446464.1, NP_000041.2
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46530 Da
Antigen Region 281-310 aa
Additional Information
Gene ID 445
Other Names Argininosuccinate synthase, Citrulline--aspartate ligase, ASS1, ASS
Target/Specificity This ASS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-310 amino acids from the C-terminal region of human ASS1.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsASS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASS1 (HGNC:758)
Function One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Cellular Location Cytoplasm, cytosol
Tissue Location Expressed in adult liver.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.

References

Hozyasz, K.K., et al. Arch. Oral Biol. 55(11):861-866(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kobayashi, E., et al. Mol. Cancer Ther. 9(3):535-544(2010)
Tsai, W.B., et al. Mol. Cancer Ther. 8(12):3223-3233(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 182.50
$ 70.00
Cat# AP12606b
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