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NXN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q6DKJ4 |
| Other Accession | Q6GM16, P97346, NP_071908.2 |
| Reactivity | Mouse |
| Predicted | Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48392 Da |
| Antigen Region | 221-249 aa |
| Gene ID | 64359 |
|---|---|
| Other Names | Nucleoredoxin, NXN, NRX |
| Target/Specificity | This NXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human NXN. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NXN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NXN |
|---|---|
| Synonyms | NRX |
| Function | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97346}. Nucleus {ECO:0000250|UniProtKB:P97346} |
Provided below are standard protocols that you may find useful for product applications.
Background
NXN functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A (By similarity).
References
Ollila, H.M., et al. Mol. Psychiatry 14(4):351-353(2009)
Funato, Y., et al. Antioxid. Redox Signal. 9(8):1035-1057(2007)
Hirota, K., et al. Biochem. Biophys. Res. Commun. 274(1):177-182(2000)
Kurooka, H., et al. Genomics 39(3):331-339(1997)
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