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> home > Products > Primary Antibodies > Antibody Collections > Ribonucleoprotein > SNRPD3 Antibody (N-term)
SNRPD3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | P62318 |
| Other Accession | P62323, P62320, O44437, NP_004166.1 |
| Reactivity | Human, Mouse |
| Predicted | Drosophila, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 13916 Da |
| Antigen Region | 9-38 aa |
| Gene ID | 6634 |
|---|---|
| Other Names | Small nuclear ribonucleoprotein Sm D3, Sm-D3, snRNP core protein D3, SNRPD3 |
| Target/Specificity | This SNRPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human SNRPD3. |
| Dilution | WB~~1:2000 IHC-P-Leica~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRPD3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRPD3 |
|---|---|
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Note=SMN- mediated assembly into core snRNPs occurs in the cytosol before SMN- mediated transport to the nucleus to be included in spliceosomes |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
References
Gonsalvez, G.B., et al. J. Cell Biol. 178(5):733-740(2007)
Ma, Y., et al. Structure 13(6):883-892(2005)
Mahler, M., et al. Arthritis Res. Ther. 7 (1), R19-R29 (2005) :
Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)
Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)
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$ 365.00
$ 140.00
Cat# AP12451A
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