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MYBPC3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q14896 |
| Other Accession | P56741, O70468, NP_000247.2 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 140762 Da |
| Antigen Region | 189-218 aa |
| Gene ID | 4607 |
|---|---|
| Other Names | Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3 |
| Target/Specificity | This MYBPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3. |
| Dilution | WB~~1:2000 IHC-P~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYBPC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYBPC3 |
|---|---|
| Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
Provided below are standard protocols that you may find useful for product applications.
Background
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
References
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Brion, M., et al. Ann. Clin. Lab. Sci. 40(3):285-289(2010)
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