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DLL3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, IF, WB, E |
|---|---|
| Primary Accession | Q9NYJ7 |
| Other Accession | NP_058637.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64618 Da |
| Antigen Region | 545-573 aa |
| Gene ID | 10683 |
|---|---|
| Other Names | Delta-like protein 3, Drosophila Delta homolog 3, Delta3, DLL3 |
| Target/Specificity | This DLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 545-573 amino acids from the C-terminal region of human DLL3. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DLL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DLL3 |
|---|---|
| Function | Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
References
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Heuss, S.F., et al. Proc. Natl. Acad. Sci. U.S.A. 105(32):11212-11217(2008)
Maisenbacher, M.K., et al. Hum. Genet. 116(5):416-419(2005)
Whittock, N.V., et al. Clin. Genet. 66(1):67-72(2004)
Bonafe, L., et al. Clin. Genet. 64(1):28-35(2003)
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