ZNF146 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q15072 |
Other Accession | NP_001093109.1, NP_001093108.1, NP_009076.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33308 Da |
Antigen Region | 17-45 aa |
Gene ID | 7705 |
---|---|
Other Names | Zinc finger protein OZF, Only zinc finger protein, Zinc finger protein 146, ZNF146, OZF |
Target/Specificity | This ZNF146 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ZNF146. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZNF146 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZNF146 |
---|---|
Synonyms | OZF |
Cellular Location | Nucleus. |
Tissue Location | Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The ZNF146 protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. ZNF146 overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore ZNF146 function may be linked to telomere regulation. ZNF146 is strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. ZNF146 is overexpresseed in 80% of colorectal cancers.
References
Antoine, K., et al. J. Cell. Biochem. 95(4):763-768(2005)
Antoine, K., et al. Mol. Cell. Biochem. 271 (1-2), 215-223 (2005) :
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Ferbus, D., et al. J. Pathol. 200(2):177-182(2003)
Pibouin, L., et al. Cytogenet. Cell Genet. 92 (1-2), 80-84 (2001) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.