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TGFB1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P01137 |
| Other Accession | P17246, P07200, P04202, P18341, NP_000651.3, O19011 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Horse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44325 Da |
| Antigen Region | 30-50 aa |
| Gene ID | 7040 |
|---|---|
| Other Names | Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB |
| Target/Specificity | This TGFB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-50 amino acids of human TGFB1. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TGFB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFB1 (HGNC:11766) |
|---|---|
| Synonyms | TGFB |
| Function | Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. |
| Cellular Location | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix |
| Tissue Location | Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158) |
Provided below are standard protocols that you may find useful for product applications.
Background
TGFB1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
References
Perez, A.B., et al. Hum. Immunol. 71(11):1135-1140(2010) Xu, Z., et al. Biochem. Biophys. Res. Commun. 401(3):376-381(2010) Bran, G.M., et al. Anticancer Res. 30(9):3459-3463(2010) Zauli, G., et al. Blood 80(12):3036-3043(1992) Wrana, J.L., et al. Cell 71(6):1003-1014(1992)
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