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AQP5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P55064 |
| Other Accession | NP_001642.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28292 Da |
| Antigen Region | 227-256 aa |
| Gene ID | 362 |
|---|---|
| Other Names | Aquaporin-5, AQP-5, AQP5 |
| Target/Specificity | This AQP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the C-terminal region of human AQP5. |
| Dilution | WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AQP5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AQP5 (HGNC:638) |
|---|---|
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:18768791, PubMed:8621489). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Hypotonicity increases location at the cell membrane Phosphorylation decreases location at the cell membrane |
| Tissue Location | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.
References
Shen, Y., et al. Respir Physiol Neurobiol 171(3):212-217(2010)
Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)
Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :
Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :
Nejsum, L.N., et al. Proc. Natl. Acad. Sci. U.S.A. 99(1):511-516(2002)
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