TOE1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q96GM8 |
Other Accession | NP_079353.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 56548 Da |
Antigen Region | 90-117 aa |
Gene ID | 114034 |
---|---|
Other Names | Target of EGR1 protein 1, TOE1 |
Target/Specificity | This TOE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the N-terminal region of human TOE1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TOE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TOE1 |
---|---|
Function | Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684). |
Cellular Location | Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TOE1 inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
De Belle, I., et al. J. Biol. Chem. 278(16):14306-14312(2003)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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