SNIP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
---|---|
Primary Accession | Q8TAD8 |
Other Accession | Q5M9G6, Q8BIZ6, NP_078976.2 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45778 Da |
Antigen Region | 91-118 aa |
Gene ID | 79753 |
---|---|
Other Names | Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1 |
Target/Specificity | This SNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the N-terminal region of human SNIP1. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SNIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SNIP1 |
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Function | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
Cellular Location | Nucleus |
Tissue Location | Ubiquitous, with highest expression in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. SNIP1 is involved in the microRNA (miRNA) biogenesis.
References
Bracken, C.P., et al. Cancer Res. 68(18):7621-7628(2008)
Yu, B., et al. Proc. Natl. Acad. Sci. U.S.A. 105(29):10073-10078(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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