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TTBK2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q6IQ55 |
| Other Accession | Q3UVR3, NP_775771.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 137412 Da |
| Antigen Region | 217-245 aa |
| Gene ID | 146057 |
|---|---|
| Other Names | Tau-tubulin kinase 2, TTBK2, KIAA0847 |
| Target/Specificity | This TTBK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the N-terminal region of human TTBK2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTBK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTBK2 |
|---|---|
| Synonyms | KIAA0847 |
| Function | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). |
| Cellular Location | Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:23141541). May also be present in cytosol and, at lower level in the nucleus (PubMed:21548880) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xu, Q., et al. Neurol. Sci. 31(1):107-109(2010)
Edener, U., et al. J. Neurol. 256(11):1856-1859(2009)
Houlden, H., et al. Nat. Genet. 39(12):1434-1436(2007)
Kitano-Takahashi, M., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 7), 602-604 (2007) :
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